Photoshop+Illustrator. Photoshop: Owl, flowers and leaves were photos, backgrounds removed. I used a ‘cartoon’ Action I purchased to give it more of a graphic look. Sharpen tool, Vibrance/Saturation adjustment layer, drop shadows. Then I brought it into Illustrator to do the text and glasses. Drop shadows, Appearance panel strokes, ‘black’ stroke is 0% opacity knockout- kind of a rare trick that I rarely see mentioned in tutorials, ‘Stipple’ plugin for the dots (Astute Graphics).